Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK049781-01A1
Application #
2150694
Study Section
Endocrinology Study Section (END)
Project Start
1996-06-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Physiology
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Watson, Robert T; Furukawa, Megumi; Chiang, Shian-Huey et al. (2003) The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes. Mol Cell Biol 23:961-74
Watson, R T; Shigematsu, S; Chiang, S H et al. (2001) Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. J Cell Biol 154:829-40
Kao, A W; Yang, C; Pessin, J E (2000) Functional comparison of the role of dynamin 2 splice variants on GLUT-4 endocytosis in 3T3L1 adipocytes. Am J Physiol Endocrinol Metab 278:E825-31
Fucini, R V; Okada, S; Pessin, J E (1999) Insulin-induced desensitization of extracellular signal-regulated kinase activation results from an inhibition of Raf activity independent of Ras activation and dissociation of the Grb2-SOS complex. J Biol Chem 274:18651-8
Elmendorf, J S; Boeglin, D J; Pessin, J E (1999) Temporal separation of insulin-stimulated GLUT4/IRAP vesicle plasma membrane docking and fusion in 3T3L1 adipocytes. J Biol Chem 274:37357-61
Okada, S; Matsuda, M; Anafi, M et al. (1998) Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes. EMBO J 17:2554-65
Zhao, H; Okada, S; Pessin, J E et al. (1998) Insulin receptor-mediated dissociation of Grb2 from Sos involves phosphorylation of Sos by kinase(s) other than extracellular signal-regulated kinase. J Biol Chem 273:12061-7
Okada, S; Pessin, J E (1997) Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex. J Biol Chem 272:28179-82