Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK049845-08
Application #
6696995
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Malozowski, Saul N
Project Start
1996-06-01
Project End
2005-11-30
Budget Start
2003-01-01
Budget End
2003-11-30
Support Year
8
Fiscal Year
2003
Total Cost
$220,500
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zhang, Sherry; Lu, Chunxia; Das, Arun K et al. (2018) Abrogation of GH action in Kupffer cells results in increased hepatic CD36 expression and exaggerated nonalcoholic fatty liver disease. Growth Horm IGF Res 42-43:74-79
Lu, Chunxia; Kumar, P Anil; Sun, Jinhong et al. (2013) Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity. J Biol Chem 288:15725-35
Kumar, P Anil; Brosius 3rd, Frank C; Menon, Ram K (2011) The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy. Curr Diabetes Rev 7:50-5
Sun, Jinhong; Kumar, P Anil; Thimmarayappa, Jamuna et al. (2011) Esterase 1 is a novel transcriptional repressor of growth hormone receptor gene expression: a unique noncatalytic role for a carboxyesterase protein. Mol Endocrinol 25:1351-63
Lu, Chunxia; Kumar, P Anil; Fan, Yong et al. (2010) A novel effect of growth hormone on macrophage modulates macrophage-dependent adipocyte differentiation. Endocrinology 151:2189-99
Kumar, P Anil; Kotlyarevska, Kateryna; Dejkhmaron, Prapai et al. (2010) Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy. J Biol Chem 285:31148-56
Fan, Yong; Menon, Ram K; Cohen, Pinchas et al. (2009) Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem 284:19937-44
Thomas, Inas H; Saini, Natinder K; Adhikari, Amita et al. (2009) Neonatal diabetes mellitus with pancreatic agenesis in an infant with homozygous IPF-1 Pro63fsX60 mutation. Pediatr Diabetes 10:492-6