The goal of this research program is to evaluate new biologic functions of parathyroid hormone related peptide (PTHrP). This will be accomplished by evaluating the biologic activities of parathyroid/parathyroid related peptide (PTH/PTHrP) in vivo in C57 BL-6 mice. The effect of selected PTH/PTHrP agonists and antagonists will be evaluated on the: 1) induction of anagen hair growth in telogen mice, 2) inhibition of catagen hair maturation in anagen mice, and 3) maintenance of anagen hair growth in anagen mice. The second goal of this research program is to evaluate the biologic activity and mechanism of action of PTH/PTHrP agonists and antagonists on hair growth in cultured hair follicles and in organ hair cultures from C57 BL-6 mice, PTHrP knockout mice, PTHrP receptor knockout mice and their normal litter mates.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050102-02
Application #
2634284
Study Section
General Medicine B Study Section (GMB)
Program Officer
Margolis, Ronald N
Project Start
1997-01-01
Project End
2000-12-31
Budget Start
1998-01-26
Budget End
1998-12-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Holick, M F (2001) Calciotropic hormones and the skin: a millennium perspective. J Cosmet Sci 52:146-8
Peters, E M; Foitzik, K; Paus, R et al. (2001) A new strategy for modulating chemotherapy-induced alopecia, using PTH/PTHrP receptor agonist and antagonist. J Invest Dermatol 117:173-8
Zanello, S B; Jackson, D M; Holick, M F (2000) Expression of the circadian clock genes clock and period1 in human skin. J Invest Dermatol 115:757-60