Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050110-02
Application #
2151120
Study Section
Metabolism Study Section (MET)
Project Start
1995-09-01
Project End
1999-07-31
Budget Start
1996-09-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Mizuno, T M; Makimura, H; Silverstein, J et al. (1999) Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology 140:4551-7
Bergen, H T; Mizuno, T; Taylor, J et al. (1999) Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus. Brain Res 851:198-203
Yang, X J; Kow, L M; Funabashi, T et al. (1999) Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms. Diabetes 48:1763-72
Mizuno, T M; Mobbs, C V (1999) Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140:814-7
Mizuno, T M; Kleopoulos, S P; Bergen, H T et al. (1998) Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47:294-7
Bergen, H T; Mizuno, T M; Taylor, J et al. (1998) Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology 139:4483-8
Sugiyama, A; Hattori, S; Tanaka, S et al. (1997) Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice. Horm Metab Res 29:599-603
Mizuno, T M; Bergen, H; Funabashi, T et al. (1996) Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proc Natl Acad Sci U S A 93:3434-8
Mizuno, T; Bergen, H; Kleopoulos, S et al. (1996) Effects of nutritional status and aging on leptin gene expression in mice: importance of glucose. Horm Metab Res 28:679-84