Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK054058-03
Application #
2906232
Study Section
Metabolism Study Section (MET)
Program Officer
Laughlin, Maren R
Project Start
1997-09-30
Project End
2001-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Clerk, Lucy H; Vincent, Michelle A; Barrett, Eugene J et al. (2007) Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition. Am J Physiol Endocrinol Metab 293:E1804-9
Liu, Zhenqi; Long, Wen; Fryburg, David A et al. (2006) The regulation of body and skeletal muscle protein metabolism by hormones and amino acids. J Nutr 136:212S-7S
Clerk, Lucy H; Vincent, Michelle A; Jahn, Linda A et al. (2006) Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes 55:1436-42
Vincent, Michelle A; Clerk, Lucy H; Lindner, Jonathan R et al. (2006) Mixed meal and light exercise each recruit muscle capillaries in healthy humans. Am J Physiol Endocrinol Metab 290:E1191-7
Li, Guolian; Barrett, Eugene J; Wang, Hong et al. (2005) Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells. Endocrinology 146:4690-6
Vincent, Michelle A; Clerk, Lucy H; Lindner, Jonathan R et al. (2004) Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo. Diabetes 53:1418-23
Liu, Zhenqi; Li, Guolian; Kimball, Scot R et al. (2004) Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle. Am J Physiol Endocrinol Metab 287:E275-81
Clerk, Lucy H; Vincent, Michelle A; Lindner, Jonathan R et al. (2004) The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake. Diabetes Metab Res Rev 20:3-12
Liu, Zhenqi; Wu, Yangsong; Nicklas, Edward W et al. (2004) Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle. Am J Physiol Endocrinol Metab 286:E523-8
Wu, Yangsong; Barrett, Eugene J; Long, Wen et al. (2004) Glucocorticoids differentially modulate insulin-mediated protein and glycogen synthetic signaling downstream of protein kinase B in rat myocardium. Endocrinology 145:1161-6

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