Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK054071-03
Application #
2906238
Study Section
Hematology Subcommittee 2 (HEM)
Program Officer
Badman, David G
Project Start
1997-09-12
Project End
2002-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Fromm, George; Cadiz-Rivera, Brenda; de Vries, Christina et al. (2011) An embryonic stage-specific enhancer within the murine ?-globin locus mediates domain-wide histone hyperacetylation. Blood 117:5207-14
Coon, Charles I; Fiering, Steven; Gaudet, Justin et al. (2009) Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP. Matrix Biol 28:425-31
Lathrop, Melissa J; Hsu, Mei; Richardson, Christine A et al. (2009) Developmentally regulated extended domains of DNA hypomethylation encompass highly transcribed genes of the human beta-globin locus. Exp Hematol 37:807-813.e2
Hsu, Mei; Mabaera, Rodwell; Lowrey, Christopher H et al. (2007) CpG hypomethylation in a large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes. Mol Cell Biol 27:5047-54
Hu, Xiao; Eszterhas, Susan; Pallazzi, Nicolas et al. (2007) Transcriptional interference among the murine beta-like globin genes. Blood 109:2210-6
Hu, Xiao; Bulger, Michael; Bender, M A et al. (2006) Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes. Blood 107:821-6
Eszterhas, Susan K; Bouhassira, Eric E; Martin, David I K et al. (2002) Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position. Mol Cell Biol 22:469-79
Bender, M A; Roach, J N; Halow, J et al. (2001) Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites. Blood 98:2022-7
Bender, M A; Bulger, M; Close, J et al. (2000) Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol Cell 5:387-93
Bender, M A; Mehaffey, M G; Telling, A et al. (2000) Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region. Blood 95:3600-4

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