Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK057717-04
Application #
6753621
Study Section
General Medicine B Study Section (GMB)
Program Officer
Ketchum, Christian J
Project Start
2002-03-01
Project End
2007-02-28
Budget Start
2004-03-01
Budget End
2005-02-28
Support Year
4
Fiscal Year
2004
Total Cost
$246,500
Indirect Cost

  Institution

Name
Stevens Institute of Technology
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
064271570
City
Hoboken
State
NJ
Country
United States
Zip Code
07030

  Publications

Saxena, Sunil K; Kaur, Simarna (2006) Regulation of epithelial ion channels by Rab GTPases. Biochem Biophys Res Commun 351:582-7
Saxena, Sunil K; Singh, Madhurima; Shibata, Hiroshi et al. (2006) Rab4 GTP/GDP modulates amiloride-sensitive sodium channel (ENaC) function in colonic epithelia. Biochem Biophys Res Commun 340:726-33
Saxena, Sunil K; Horiuchi, Hisanori; Fukuda, Mitsunori (2006) Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. Biochem Biophys Res Commun 344:651-7
Saxena, Sunil K; Kaur, Simarna (2006) Rab27a negatively regulates CFTR chloride channel function in colonic epithelia: involvement of the effector proteins in the regulatory mechanism. Biochem Biophys Res Commun 346:259-67
Saxena, Sunil K; George, Constantine M; Pinskiy, Vadim et al. (2006) Epithelial sodium channel is regulated by SNAP-23/syntaxin 1A interplay. Biochem Biophys Res Commun 343:1279-85
Helms, My N; Liu, Lian; Liang, You-You et al. (2005) Phosphatidylinositol 3,4,5-trisphosphate mediates aldosterone stimulation of epithelial sodium channel (ENaC) and interacts with gamma-ENaC. J Biol Chem 280:40885-91
Ma, He-Ping; Al-Khalili, Otor; Ramosevac, Semra et al. (2004) Steroids and exogenous gamma-ENaC subunit modulate cation channels formed by alpha-ENaC in human B lymphocytes. J Biol Chem 279:33206-12