We propose to comprehensively evaluate a series of inflammatory, antigenic, and endothelial biomarkers for type 2 diabetes mellitus among participants in the Western New York Study. We will recall nearly 3000 cohort members and identify converters to type 2 DM. Using a case-control approach, we will test the following Specific Aims: 1) determine if biomarkers of chronic inflammation including CRP, TNFalpha, IL6 predict incident DM; 2) evaluate whether markers of endothelial function including E-selectin, sICAM1, and sVCAM1 predict DM; and 3) determine if antibodies to glutamic acid decarboxylase (GAD) and IA2 identify a subtype of phenotypic type 2 diabetic persons. We hypothesize that chronic dysregulation of the immune system is a potent predictor of type 2 DM. Cases will be persons who have developed type 2 DM since their baseline examination in 1996- 1998. We propose to control for sex, race, year of baseline exam, and baseline glycemic category in the design phase of the study. Controls will be matched 3:1 to the cases on these variables. Baseline information on risk factors including age, body fat, lipoproteins, physical activity, family history of DM, and smoking will be used to evaluate confounding and effect modification. Baseline plasma samples that will provide the exposure information have been collected, handled, and frozen with a high level of standardization and precision with immediate on-site centrifugation and freezing in our Biological Specimen Bank. The exposures proposed represent state-of-the-art measures and will be assayed in laboratories that serve as CORE labs for several national studies. The proposed research is of great importance due to the epidemic nature of type 2 DM, and the promise that it may be preventable. A better understanding of the etiology of type 2 and a better definition of the """"""""at risk"""""""" phenotype can provide health benefits for the millions at risk for acquiring DM.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK060587-02
Application #
6640213
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Blondel, Olivier
Project Start
2002-07-01
Project End
2005-05-31
Budget Start
2003-06-01
Budget End
2004-05-31
Support Year
2
Fiscal Year
2003
Total Cost
$586,341
Indirect Cost
Name
State University of New York at Buffalo
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Donahue, R P; Stranges, S; Rafalson, L et al. (2014) Risk factors for prehypertension in the community: a prospective analysis from the Western New York Health Study. Nutr Metab Cardiovasc Dis 24:162-7
Donahue, R P; Dorn, J M; Stranges, S et al. (2011) Impaired fasting glucose and recurrent cardiovascular disease among survivors of a first acute myocardial infarction: evidence of a sex difference? The Western New York experience. Nutr Metab Cardiovasc Dis 21:504-11
Rafalson, Lisa; Donahue, Richard P; Stranges, Saverio et al. (2010) Short sleep duration is associated with the development of impaired fasting glucose: the Western New York Health Study. Ann Epidemiol 20:883-9
Stranges, Saverio; Dorn, Joan M; Cappuccio, Francesco P et al. (2010) A population-based study of reduced sleep duration and hypertension: the strongest association may be in premenopausal women. J Hypertens 28:896-902
Rafalson, Lisa; Donahue, Richard P; Dmochowski, Jacek et al. (2009) Cigarette smoking is associated with conversion from normoglycemia to impaired fasting glucose: the Western New York Health Study. Ann Epidemiol 19:365-71
Stranges, Saverio; Dorn, Joan M; Shipley, Martin J et al. (2008) Correlates of short and long sleep duration: a cross-cultural comparison between the United Kingdom and the United States: the Whitehall II Study and the Western New York Health Study. Am J Epidemiol 168:1353-64
Stranges, Saverio; Rafalson, Lisa B; Dmochowski, Jacek et al. (2008) Additional contribution of emerging risk factors to the prediction of the risk of type 2 diabetes: evidence from the Western New York Study. Obesity (Silver Spring) 16:1370-6
Donahue, Richard P; Rejman, Karol; Rafalson, Lisa B et al. (2007) Sex differences in endothelial function markers before conversion to pre-diabetes: does the clock start ticking earlier among women? The Western New York Study. Diabetes Care 30:354-9
Donahue, Richard P; Stranges, Saverio; Rejman, Karol et al. (2007) Elevated cystatin C concentration and progression to pre-diabetes: the Western New York study. Diabetes Care 30:1724-9
Stranges, Saverio; Trevisan, Maurizio; Dorn, Joan M et al. (2005) Body fat distribution, liver enzymes, and risk of hypertension: evidence from the Western New York Study. Hypertension 46:1186-93