Ph Sensitive Complex Hydrogel for Protein Drug Release

Peppas, Nicholas A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Biomedical Imaging and Bioengineering (NIBIB)
• Type: Research Project (R01)
• Project #: 7R01EB000246-12
• Application #: 6690258
• Study Section: Surgery and Bioengineering Study Section (SB)
• Program Officer: Moy, Peter
• Project Start: 1989-12-01
• Project End: 2003-12-31
• Budget Start: 2003-01-01
• Budget End: 2003-12-31
• Support Year: 12
• Fiscal Year: 2002
• Total Cost: $326,341

Institution

• Name: University of Texas Austin
• Department: Engineering (All Types)
• Type: Schools of Engineering
• City: Austin
• State: TX
• Country: United States
• Zip Code: 78712

Publications

Sainz, Vanessa; Moura, Liane I F; Peres, Carina et al. (2018) ?-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma. Acta Biomater 76:193-207

Sharpe, Lindsey A; Vela Ramirez, Julia E; Haddadin, Olivia M et al. (2018) pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles. Biomacromolecules 19:793-802

Steichen, Stephanie; O'Connor, Colleen; Peppas, Nicholas A (2017) Development of a P((MAA-co-NVP)-g-EG) Hydrogel Platform for Oral Protein Delivery: Effects of Hydrogel Composition on Environmental Response and Protein Partitioning. Macromol Biosci 17:

Horava, Sarena D; Peppas, Nicholas A (2016) Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX. Ann Biomed Eng 44:1970-82

Koetting, Michael Clinton; Guido, Joseph Frank; Gupta, Malvika et al. (2016) pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery. J Control Release 221:18-25

Slaughter, Brandon V; Blanchard, Aaron T; Maass, Katie F et al. (2015) Dynamic swelling behavior of interpenetrating polymer networks in response to temperature and pH. J Appl Polym Sci 132:

Spencer, David S; Puranik, Amey S; Peppas, Nicholas A (2015) Intelligent Nanoparticles for Advanced Drug Delivery in Cancer Treatment. Curr Opin Chem Eng 7:84-92

Carrillo-Conde, Brenda R; Brewer, Erik; Lowman, Anthony et al. (2015) Complexation Hydrogels as Oral Delivery Vehicles of Therapeutic Antibodies: An in Vitro and ex Vivo Evaluation of Antibody Stability and Bioactivity. Ind Eng Chem Res 54:10197-10205

Koetting, Michael C; Peters, Jonathan T; Steichen, Stephanie D et al. (2015) Stimulus-responsive hydrogels: Theory, modern advances, and applications. Mater Sci Eng R Rep 93:1-49

Caldorera-Moore, M; Maass, K; Hegab, R et al. (2015) Hybrid responsive hydrogel carriers for oral delivery of low molecular weight therapeutic agents. J Drug Deliv Sci Technol 30:352-359