In this competing renewal grant application entitled """"""""Human MRI to 9.4T and Beyond"""""""", the emphasis is on """"""""Beyond"""""""". The current grant now concluding supported the development of whole body imaging at 7T, and human head imaging to 9.4T. While refinements continue, the aims of demonstrating feasibility of human MRI at these highest field strengths were achieved. The development and advancement of parallel transmit, parallel transmitters, multi-channel transmission line arrays and B1 shimming were key technologies and methodologies to make these feats possible. Now, with the development of two new whole body MR systems, one at 10.5T for the University of Minnesota, and the other at 11.7T for CEA Neurospin in Saclay, France, a pair of new highest field MR systems are scheduled for delivery. As was the case with 7T and 9.4T, and for 3T and 4T before, magnet technology has often preceded radiofrequency technology in the evolution of MRI. Field strength has stepped ahead of our ability to use it, again. The purpose of this proposal is therefore to solve this problem for the world's most powerful magnets. Innovative new radiofrequency technology, coils, method and techniques are proposed for achieving the first head and body images from these unprecedented new fields. This effort is aimed at not only developing advanced technology and techniques required to safely harness the world's most powerful whole body MR magnets for science, but will safely achieve the highest field, highest signal, highest speed images yet.

Public Health Relevance

This application seeks renewal of the grant: """"""""Human MRI to 9.4T and """"""""Beyond."""""""" With Human MRI to 9.4T achieved, the effort of this proposal is directed to """"""""Beyond"""""""". A renewed grant will develop the radiofrequency technology and knowhow required to acquire the first, whole-body images at 10.5T and 11.7T.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Research Project (R01)
Project #
Application #
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Liu, Guoying
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
Schools of Medicine
United States
Zip Code
Wu, Xiaoping; Schmitter, Sebastian; Auerbach, Edward J et al. (2016) A generalized slab-wise framework for parallel transmit multiband RF pulse design. Magn Reson Med 75:1444-56
Wu, Xiaoping; Tian, Jinfeng; Schmitter, Sebastian et al. (2016) Distributing coil elements in three dimensions enhances parallel transmission multiband RF performance: A simulation study in the human brain at 7 Tesla. Magn Reson Med 75:2464-72
Sohn, Sung-Min; Gopinath, Anand; Vaughan, John Thomas (2016) A Compact, High Power Capable, and Tunable High Directivity Microstrip Coupler. IEEE Trans Microw Theory Tech 64:3217-3223
Sohn, Sung-Min; Vaughan, J Thomas; Lagore, Russell L et al. (2016) In vivo MR imaging with simultaneous RF transmission and reception. Magn Reson Med 76:1932-1938
Schmitter, Sebastian; Wu, Xiaoping; U?urbil, Kâmil et al. (2015) Design of parallel transmission radiofrequency pulses robust against respiration in cardiac MRI at 7 Tesla. Magn Reson Med 74:1291-305
Sohn, Sung-Min; DelaBarre, Lance; Gopinath, Anand et al. (2015) Design of an Electrically Automated RF Transceiver Head Coil in MRI. IEEE Trans Biomed Circuits Syst 9:725-32
Liu, Jiaen; Zhang, Xiaotong; Schmitter, Sebastian et al. (2015) Gradient-based electrical properties tomography (gEPT): A robust method for mapping electrical properties of biological tissues in vivo using magnetic resonance imaging. Magn Reson Med 74:634-46
Keith, Graeme A; Rodgers, Christopher T; Hess, Aaron T et al. (2015) Automated tuning of an eight-channel cardiac transceive array at 7 tesla using piezoelectric actuators. Magn Reson Med 73:2390-7
Wu, Xiaoping; Zhang, Xiaotong; Tian, Jinfeng et al. (2015) Comparison of RF body coils for MRI at 3??T: a simulation study using parallel transmission on various anatomical targets. NMR Biomed 28:1332-44
Rodgers, Christopher T; Clarke, William T; Snyder, Carl et al. (2014) Human cardiac 31P magnetic resonance spectroscopy at 7 Tesla. Magn Reson Med 72:304-15

Showing the most recent 10 out of 38 publications