Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
1R01ES004200-01
Application #
3252194
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1987-09-01
Project End
1990-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Texas Austin
Department
Type
Schools of Pharmacy
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78713
Hezari, M; Davis, P J (1993) Microbial models of mammalian metabolism. Furosemide glucoside formation using the fungus Cunninghamella elegans. Drug Metab Dispos 21:259-67
Yang, W; Jiang, T; Acosta, D et al. (1993) Microbial models of mammalian metabolism: involvement of cytochrome P450 in the N-demethylation of N-methylcarbazole by Cunninghamella echinulata. Xenobiotica 23:973-82
Hezari, M; Davis, P J (1992) Microbial models of mammalian metabolism. N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans. Drug Metab Dispos 20:882-8
Yang, W; Davis, P J (1992) Microbial models of mammalian metabolism. Biotransformations of N-methylcarbazole using the fungus Cunninghamella echinulata. Drug Metab Dispos 20:38-46
Yang, W; Jiang, T; Acosta, D et al. (1992) Production of a toxic, novel mammalian metabolite of N-methylcarbazole predicted by a fungal cell model of mammalian metabolism. Toxicol Lett 60:307-14
Wong, Y W; Davis, P J (1991) Microbial models of mammalian metabolism: production of 3'-hydroxywarfarin, a new metabolite of warfarin using Cunninghamella elegans. J Pharm Sci 80:305-8
Yang, W; Jiang, T R; Davis, P J et al. (1991) In vitro metabolism and toxicity assessment of N-methylcarbazole in primary cultured rat hepatocytes. Toxicology 68:217-26
Davila, J C; Dorantes, A; Stavchansky, S A et al. (1991) The cytotoxicity of p-chloro-m-xylenol in primary culture of rat hepatocytes. Pharm Res 8:656-7
Davila, J C; Davis, P J; Acosta, D (1991) Changes in glutathione and cellular energy as potential mechanisms of papaverine-induced hepatotoxicity in vitro. Toxicol Appl Pharmacol 108:28-36
Davila, J C; Reddy, C G; Davis, P J et al. (1990) Toxicity assessment of papaverine hydrochloride and papaverine-derived metabolites in primary cultures of rat hepatocytes. In Vitro Cell Dev Biol 26:515-24

Showing the most recent 10 out of 17 publications