There are two major ongoing projects in my laboratory: 1. Transcription factors that establish and maintain T-cell specific gene expression. TCF-1 and HES-1 are transcription factors that impose T cell identity early in T cell development, but the mechanisms employed are uncertain, and are the focus of intense investigation in our laboratory. We currently think HES-1 represses genes involved in development of non-T cell lineages, whereas TCF-1 may drive T-lineage specific gene expression. We're using conditional alleles of TCF-1 to determine whether TCF-1 controls expression of a common set of T cell genes throughout development, or if TCF-1 instead plays different roles in mature T cells. 2. The development and function of innate lymphoid cells. Innate lymphoid cells have transcriptional programs that appear to mirror those of T cells. The comparison of innate lymphocyte cell development with T cell development provides an opportunity to understand the factors that underlie the shared as well as the unique features and functions of these apparently closely related cell lineages.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011633-02
Application #
9344009
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Johnson, John L; Georgakilas, Georgios; Petrovic, Jelena et al. (2018) Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells. Immunity 48:243-257.e10
Das, Arundhoti; Harly, Christelle; Yang, Qi et al. (2018) Lineage specification in innate lymphocytes. Cytokine Growth Factor Rev 42:20-26
Smith, Michelle J; Reichenbach, Dawn K; Parker, Sarah L et al. (2017) T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction. JCI Insight 2:
Zhang, Kangning; Xu, Xingyuan; Pasha, Muhammad Asghar et al. (2017) Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells. J Immunol 198:1798-1803
Larsen, Brian M; Bhandoola, Avinash (2017) A novel role for p53 in self-tolerance. Blood 130:388-389
Nish, Simone A; Zens, Kyra D; Kratchmarov, Radomir et al. (2017) CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions. J Exp Med 214:39-47
Harly, Christelle; Bhandoola, Avinash (2016) A doppelgänger of T cell development. Cell Cycle 15:479-80
Manna, Sugata; Bhandoola, Avinash (2016) Intrathymic Injection. Methods Mol Biol 1323:203-9
Yang, Qi; Ge, Moyar Q; Kokalari, Blerina et al. (2016) Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 137:571-8
Cowan, Jennifer; Bhandoola, Avinash (2016) Progress on thymic function from Maui. Nat Immunol 17:1129-32

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