There are two major ongoing projects in my laboratory: 1. Transcription factors that establish and maintain T-cell specific gene expression. TCF-1 and HES-1 are transcription factors that impose T cell identity early in T cell development, but the mechanisms employed are uncertain, and are the focus of intense investigation in our laboratory. We currently think HES-1 represses genes involved in development of non-T cell lineages, whereas TCF-1 may drive T-lineage specific gene expression. We're using conditional alleles of TCF-1 to determine whether TCF-1 controls expression of a common set of T cell genes throughout development, or if TCF-1 instead plays different roles in mature T cells. 2. The development and function of innate lymphoid cells. Innate lymphoid cells have transcriptional programs that appear to mirror those of T cells. The comparison of innate lymphocyte cell development with T cell development provides an opportunity to understand the factors that underlie the shared as well as the unique features and functions of these apparently closely related cell lineages.
| Johnson, John L; Georgakilas, Georgios; Petrovic, Jelena et al. (2018) Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells. Immunity 48:243-257.e10 |
| Das, Arundhoti; Harly, Christelle; Yang, Qi et al. (2018) Lineage specification in innate lymphocytes. Cytokine Growth Factor Rev 42:20-26 |
| Smith, Michelle J; Reichenbach, Dawn K; Parker, Sarah L et al. (2017) T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction. JCI Insight 2: |
| Zhang, Kangning; Xu, Xingyuan; Pasha, Muhammad Asghar et al. (2017) Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells. J Immunol 198:1798-1803 |
| Larsen, Brian M; Bhandoola, Avinash (2017) A novel role for p53 in self-tolerance. Blood 130:388-389 |
| Nish, Simone A; Zens, Kyra D; Kratchmarov, Radomir et al. (2017) CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions. J Exp Med 214:39-47 |
| Morgado-Palacin, Isabel; Day, Amanda; Murga, Matilde et al. (2016) Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Sci Signal 9:ra91 |
| Harly, Christelle; Bhandoola, Avinash (2016) A doppelgänger of T cell development. Cell Cycle 15:479-80 |
| Manna, Sugata; Bhandoola, Avinash (2016) Intrathymic Injection. Methods Mol Biol 1323:203-9 |
| Yang, Qi; Ge, Moyar Q; Kokalari, Blerina et al. (2016) Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 137:571-8 |
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