Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006841-08
Application #
2155754
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1988-08-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Biology
Type
Schools of Veterinary Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Zeng, Fang-Mao; Liu, Ling-Yan; Zheng, Jin et al. (2016) Identification of a Fused-Ring 2'-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1-Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene. Chem Res Toxicol 29:1041-50
Liu, Xin-Jie; Zeng, Fang-Mao; An, Jing et al. (2013) Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene. Toxicol Appl Pharmacol 271:13-9
Sun, Liang; Pelah, Avishay; Zhang, Dong-Ping et al. (2013) Formation of fused-ring 2'-deoxycytidine adducts from 1-chloro-3-buten-2-one, an in vitro 1,3-butadiene metabolite, under in vitro physiological conditions. Chem Res Toxicol 26:1545-53
Elfarra, Adnan A; Zhang, Xin-Yu (2012) Alcohol dehydrogenase- and rat liver cytosol-dependent bioactivation of 1-chloro-2-hydroxy-3-butene to 1-chloro-3-buten-2-one, a bifunctional alkylating agent. Chem Res Toxicol 25:2600-7
Barshteyn, Nella; Krause, Renee J; Elfarra, Adnan A (2007) Mass spectral analyses of hemoglobin adducts formed after in vitro exposure of erythrocytes to hydroxymethylvinyl ketone. Chem Biol Interact 166:176-81
Zhang, Xin-Yu; Elfarra, Adnan A (2006) Characterization of 1,2,3,4-diepoxybutane-2'-deoxyguanosine cross-linking products formed at physiological and nonphysiological conditions. Chem Res Toxicol 19:547-55
Zhang, Xin-Yu; Elfarra, Adnan A (2005) Reaction of 1,2,3,4-diepoxybutane with 2'-deoxyguanosine: initial products and their stabilities and decomposition patterns under physiological conditions. Chem Res Toxicol 18:1316-23
Sprague, Christopher L; Elfarra, Adnan A (2005) Protection of rats against 3-butene-1,2-diol-induced hepatotoxicity and hypoglycemia by N-acetyl-l-cysteine. Toxicol Appl Pharmacol 207:266-74
Zhang, Xin-Yu; Elfarra, Adnan A (2004) Characterization of the reaction products of 2'-deoxyguanosine and 1,2,3,4-diepoxybutane after acid hydrolysis: formation of novel guanine and pyrimidine adducts. Chem Res Toxicol 17:521-8
Sprague, Christopher L; Phillips, Lynette A; Young, Karen M et al. (2004) Species and tissue differences in the toxicity of 3-butene-1,2-diol in male Sprague-Dawley rats and B6C3F1 mice. Toxicol Sci 80:3-13

Showing the most recent 10 out of 29 publications