The principal investigator has recently generated mice that lack g-glutamyl transpeptidase (hereafter referred to as GGT), a critical enzyme in the g-glutamy cycle and glutathione metabolism. He now aims to use these GGT- deficient mice for four purposes: 1) to determine why deficient mice lag in growth and sexual maturation; 2) if deficient mice contain other GGT-like activities; 3) to more fully characterize the role of GGT in glutathione and amino acid metabolism; and 4) to examine the role of GGT metabolic pathways in two induced disease states, galactosamine/endotoxin induced liver injury and methylmercury metabolism and toxicity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES007827-02
Application #
2377916
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1996-03-01
Project End
2001-02-28
Budget Start
1997-03-01
Budget End
1998-02-28
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Pathology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
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