Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES009702-03
Application #
6382276
Study Section
Special Emphasis Panel (ZRG4-ALTX-1 (01))
Program Officer
Packenham, Joan P
Project Start
1999-05-05
Project End
2003-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
3
Fiscal Year
2001
Total Cost
$243,706
Indirect Cost
Name
University of Rochester
Department
Public Health & Prev Medicine
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Gasiewicz, Thomas A; Henry, Ellen C; Collins, Loretta L (2008) Expression and activity of aryl hydrocarbon receptors in development and cancer. Crit Rev Eukaryot Gene Expr 18:279-321
Henry, E C; Gasiewicz, T A (2008) Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor. Arch Biochem Biophys 472:77-88
Bemis, Jeffrey C; Alejandro, Napoleon F; Nazarenko, Daniel A et al. (2007) TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue. Toxicol Sci 95:240-8
Kim, Sun-Hee; Henry, Ellen C; Kim, Dong-Kyu et al. (2006) Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol 69:1871-8
Henry, E C; Bemis, J C; Henry, O et al. (2006) A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo. Arch Biochem Biophys 450:67-77
Martey, C A; Baglole, C J; Gasiewicz, T A et al. (2005) The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 289:L391-9
Palermo, Christine M; Westlake, Claire A; Gasiewicz, Thomas A (2005) Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein. Biochemistry 44:5041-52
Joiakim, Aby; Mathieu, Patricia A; Palermo, Christine et al. (2003) The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor. Drug Metab Dispos 31:1279-82
Zhou, Jun-Guo; Henry, Ellen C; Palermo, Christine M et al. (2003) Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements. Mol Pharmacol 63:915-24
Henry, E C; Gasiewicz, T A (2003) Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis. Mol Pharmacol 63:392-400

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