CYP Genes and the Generation of Oxidative Stress

Stegeman, John J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Research Project (R01)
• Project #: 1R01ES015912-01
• Application #: 7326007
• Study Section: Special Emphasis Panel (ZES1-SET-A (P1))
• Program Officer: Heindel, Jerrold
• Project Start: 2007-05-10
• Project End: 2012-02-29
• Budget Start: 2007-05-10
• Budget End: 2008-02-29
• Support Year: 1
• Fiscal Year: 2007
• Total Cost: $633,754

Institution

• Name: Woods Hole Oceanographic Institution
• Department: Biology
• Type: Other Domestic Higher Education
• DUNS #: 001766682
• City: Woods Hole
• State: MA
• Country: United States
• Zip Code: 02543

Publications

Wincent, Emma; Stegeman, John J; Jönsson, Maria E (2015) Combination effects of AHR agonists and Wnt/?-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions. Toxicol Appl Pharmacol 284:163-79

Stegeman, John J; Behrendt, Lars; Woodin, Bruce R et al. (2015) Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast. Biochim Biophys Acta 1850:2340-52

Hahn, Mark E; Timme-Laragy, Alicia R; Karchner, Sibel I et al. (2015) Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio). Free Radic Biol Med 88:275-289

Kubota, Akira; Goldstone, Jared V; Lemaire, Benjamin et al. (2015) Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish. Toxicol Sci 143:398-407

Tokunaga, Saimi; Stegeman, John J (2014) Elimination of nonspecific bands in non-radioactive electrophoretic mobility shift assays using the digoxigenin system. Anal Biochem 465:70-2

Teraoka, Hiroki; Okuno, Yuki; Nijoukubo, Daisuke et al. (2014) Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish. Aquat Toxicol 154:19-26

Hahn, Mark E; McArthur, Andrew G; Karchner, Sibel I et al. (2014) The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. PLoS One 9:e113158

Timme-Laragy, Alicia R; Goldstone, Jared V; Imhoff, Barry R et al. (2013) Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free Radic Biol Med 65:89-101

Zanette, Juliano; Jenny, Matthew J; Goldstone, Jared V et al. (2013) Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis. Aquat Toxicol 128-129:101-12

Williams, Larissa M; Timme-Laragy, Alicia R; Goldstone, Jared V et al. (2013) Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS One 8:e79574