Abstract

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Public Health Relevance

This study, by teaming together neurotoxicologist, molecular neurobiologist, medical imaging specialist and synchrotron physicist, will explore novel pathways of Pb?affected A? transport by brain barrier systems and will define the role of Pb exposure in AD pathogenesis. Results of this study will provide clues as to whether exposure to toxic Pb in the general population may contribute to the AD etiology. Potential discovery of A? transporters and metabolic regulatory mechanism in the brain barrier systems will help develop novel strategies for diagnosis, treatment and prevention of Alzheimer?s disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES027078-04S1
Application #
10038617
Study Section
Neurotoxicology and Alcohol Study Section (NAL)
Program Officer
Hollander, Jonathan
Project Start
2017-08-15
Project End
2022-07-31
Budget Start
2020-09-23
Budget End
2021-07-31
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Other Health Professions
Type
Schools of Public Health
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Rolle-McFarland, Danelle; Liu, Yingzi; Zhou, Jieqiong et al. (2018) Development of a Cumulative Exposure Index (CEI) for Manganese and Comparison with Bone Manganese and Other Biomarkers of Manganese Exposure. Int J Environ Res Public Health 15:
Sun, Liping; Wang, Keyue; Li, Yan et al. (2017) Vanadium exposure-induced striatal learning and memory alterations in rats. Neurotoxicology 62:124-129