Abstract

A variety of psychophysical, physical, electrophysiological, pupillographic and other tests are applied to normal and abnormal eyes to elucidate fundamental properties of normal vision. Of interest are night vision, dark and light adaptation, color vision, color blindness, and night blindness. The role of rhodopsin and cone visual pigments in such abnormalities is being elucidated, with the aid of biophysical measurements in vivo of the kinetics of their bleaching and regeneration with a retinal densitometer. The biophysics of excitation of photoreceptors as a function of the angle of incidence of the light upon them is also under study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY000197-28
Application #
3255175
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1978-09-01
Project End
1988-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
28
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Sieving, P A; Richards, J E; Naarendorp, F et al. (1995) Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation. Proc Natl Acad Sci U S A 92:880-4
Perlman, I; Itzhaki, A; Malik, S et al. (1994) The action spectra of cone photoreceptors in the turtle (Mauremys caspica) retina. Vis Neurosci 11:243-52
Alpern, M; Sack Jr, G H; Krantz, D H et al. (1993) Chromosomal rearrangement segregating with adrenoleukodystrophy: associated changes in color vision. Proc Natl Acad Sci U S A 90:9494-8
Sack Jr, G H; Alpern, M; Webster, T et al. (1993) Chromosomal rearrangement segregating with adrenoleukodystrophy: a molecular analysis. Proc Natl Acad Sci U S A 90:9489-93
Alpern, M; Zhang, H Z; Noji, J (1990) Do deviations from radiance-invariance of metameric matches contradict the three pigment theory of foveal trichromacy? Vision Res 30:1539-53
Alpern, M; Noji, J (1990) The change in the neutral point of dichromats with change in the angle of incidence of monochromatic light on the retina. Optom Vis Sci 67:578-82
Alpern, M (1989) The Charles Prentice award lecture 1988: the directionality of color matches and its relation to secondary protanomalous trichromacy. Optom Vis Sci 66:339-54
Alpern, M; Kitahara, H; Fielder, G H (1987) The change in color matches with retinal angle of incidence of the colorimeter beams. Vision Res 27:1763-78
Alpern, M; Fulton, A B; Baker, B N (1987) ""Self-screening"" of rhodopsin in rod outer segments. Vision Res 27:1459-70
Alpern, M (1987) A note on the action spectrum of human rod vision. Vision Res 27:1471-80

Showing the most recent 10 out of 12 publications