Abstract

Several parallel channel and feedback loops have been identified in the mammalian visual and oculomotor systems. In order to better understand the dynamics of interactive information processing implied by such circuitry, our approach is to selectively and reversibly disrupt various input channels and feedback loops while we examine either the visual capacities of animals or the activity of single cells in visual and oculomotor structures. The work will be carried out on alert, trained animals involving mostly rhesus monkeys. We will examine (1) how the ON/OFF and the color-opponent/broad-band systems originating in the retina contribute to vision and visually guided eye movement, (2) how the responses of single cells to behaviorally relevant and irrelevant stimuli are influenced by various channels and feedback loops in the lateral geniculate nucleus and the visual cortex (V1-V4), and (3) how the frontal eye fields, the superior colliculi and inputs to these two structures interact to produce visually guided eye movements.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY000676-15
Application #
3255501
Study Section
Biopsychology Study Section (BPO)
Project Start
1979-05-01
Project End
1989-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
15
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code

  Publications

Schiller, Peter H; Tehovnik, Edward J (2005) Neural mechanisms underlying target selection with saccadic eye movements. Prog Brain Res 149:157-71
Schiller, Peter H; Kendall, Jennifer (2004) Temporal factors in target selection with saccadic eye movements. Exp Brain Res 154:154-9
Cao, An; Schiller, Peter H (2003) Neural responses to relative speed in the primary visual cortex of rhesus monkey. Vis Neurosci 20:77-84
Cao, An; Schiller, Peter H (2002) Behavioral assessment of motion parallax and stereopsis as depth cues in rhesus monkeys. Vision Res 42:1953-61
Malpeli, J G (1999) Reversible inactivation of subcortical sites by drug injection. J Neurosci Methods 86:119-28
Lee, T S; Mumford, D; Romero, R et al. (1998) The role of the primary visual cortex in higher level vision. Vision Res 38:2429-54
Ferguson, T A; Griffith, T S (1997) A vision of cell death: insights into immune privilege. Immunol Rev 156:167-84
Farber, S A; Bogdanov, M; Marshall, D L et al. (1997) Excitability of neural elements within the rat corpus striatum. J Neurosci Methods 76:93-104
Sommer, M A (1997) The spatial relationship between scanning saccades and express saccades. Vision Res 37:2745-56
McPeek, R M; Schiller, P H (1994) The effects of visual scene composition on the latency of saccadic eye movements of the rhesus monkey. Vision Res 34:2293-305

Showing the most recent 10 out of 34 publications