Several parallel channel and feedback loops have been identified in the mammalian visual and oculomotor systems. In order to better understand the dynamics of interactive information processing implied by such circuitry, our approach is to selectively and reversibly disrupt various input channels and feedback loops while we examine either the visual capacities of animals or the activity of single cells in visual and oculomotor structures. The work will be carried out on alert, trained animals involving mostly rhesus monkeys. We will examine (1) how the ON/OFF and the color-opponent/broad-band systems originating in the retina contribute to vision and visually guided eye movement, (2) how the responses of single cells to behaviorally relevant and irrelevant stimuli are influenced by various channels and feedback loops in the lateral geniculate nucleus and the visual cortex (V1-V4), and (3) how the frontal eye fields, the superior colliculi and inputs to these two structures interact to produce visually guided eye movements.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY000676-17
Application #
3255503
Study Section
Biopsychology Study Section (BPO)
Project Start
1979-05-01
Project End
1989-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
17
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Schiller, Peter H; Tehovnik, Edward J (2005) Neural mechanisms underlying target selection with saccadic eye movements. Prog Brain Res 149:157-71
Schiller, Peter H; Kendall, Jennifer (2004) Temporal factors in target selection with saccadic eye movements. Exp Brain Res 154:154-9
Cao, An; Schiller, Peter H (2003) Neural responses to relative speed in the primary visual cortex of rhesus monkey. Vis Neurosci 20:77-84
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McPeek, R M; Schiller, P H (1994) The effects of visual scene composition on the latency of saccadic eye movements of the rhesus monkey. Vision Res 34:2293-305

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