The long term objectives of the proposed research are: (a) to develop a model of the functional organization of the vertebrate visual system based on comparative data from the fields of neuroanatomy, neurophysiology and neuropsychology; (b) to apply the theories and techniques of human psychophysics and scaling, information processing and perception to the animal laboratory to make use of the powerful quantitative and analytical advantages of these methods; (c) to gain a deeper understanding of the mechanisms by which specific cells groups in the vertebrate visual system, especially those that are common to most vertebrates, process visual information; (d) to exploit certain morphological and behavioral advantages that birds offer over non-human mammalian models to investigate structure-function relationships. The ultimate goal of this research is to apply the findings to a better understanding of the human visual system with a particular view towards the amelioration of visual deficits that result from injury to its central processing mechanisms.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY000735-16
Application #
3255525
Study Section
Biopsychology Study Section (BPO)
Project Start
1977-06-01
Project End
1988-05-31
Budget Start
1986-06-01
Budget End
1987-05-31
Support Year
16
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Maryland College Park
Department
Type
Schools of Arts and Sciences
DUNS #
City
College Park
State
MD
Country
United States
Zip Code
20742
Welle, Cristin G; Contreras, Diego (2016) Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry. J Neurophysiol 115:1821-35
Denman, Daniel J; Contreras, Diego (2016) On Parallel Streams through the Mouse Dorsal Lateral Geniculate Nucleus. Front Neural Circuits 10:20
Denman, Daniel J; Contreras, Diego (2015) Complex Effects on In Vivo Visual Responses by Specific Projections from Mouse Cortical Layer 6 to Dorsal Lateral Geniculate Nucleus. J Neurosci 35:9265-80
Denman, Daniel J; Contreras, Diego (2014) The structure of pairwise correlation in mouse primary visual cortex reveals functional organization in the absence of an orientation map. Cereb Cortex 24:2707-20
Fitzgerald, M E C; Tolley, E; Jackson, B et al. (2005) Anatomical and functional evidence for progressive age-related decline in parasympathetic control of choroidal blood flow in pigeons. Exp Eye Res 81:478-91
Fitzgerald, M E; Tolley, E; Frase, S et al. (2001) Functional and morphological assessment of age-related changes in the choroid and outer retina in pigeons. Vis Neurosci 18:299-317
Kunert, K S; Fitzgerald, M E; Thomson, L et al. (1999) Microglia increase as photoreceptors decrease in the aging avian retina. Curr Eye Res 18:440-7
Hodos, W; Miller, R F; Ghim, M M et al. (1998) Visual acuity losses in pigeons with lesions of the nucleus of Edinger-Westphal that disrupt the adaptive regulation of choroidal blood flow. Vis Neurosci 15:273-87
Chaves, L M; Hodos, W (1998) Color reversal-learning deficits after tectofugal pathway lesions in the pigeon telencephalon. Behav Brain Res 90:1-12
Chaves, L M; Hodos, W (1997) Hyperstriatum ventrale in pigeons: effects of lesions on color-discrimination and color-reversal learning. Vis Neurosci 14:1029-41

Showing the most recent 10 out of 24 publications