Botulinum A toxin has emerged as a useful drug for treatment of focal dystonias. The major problems with this approach are so that some patients develop antibodies to the drug, and almost all would like to see it last longer after each injection. In this project we will develop and test in animals and humans the effect of botulinum toxins B, D, E and F on eyelid and extraocular muscle function, to determine: 1) if patients who have become resistant to type A botulinum toxin can be helped by other types; 2) if these toxins have different effects than the currently used type A toxin; 3) if toxins are synergistic when used together, having either greater effect or greater duration of action than when used singly; 4) if combinations of toxins are less antigenic than individual toxins.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY008303-01
Application #
3265587
Study Section
Special Emphasis Panel (SSS (09))
Project Start
1989-12-01
Project End
1992-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
1
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Smith-Kettlewell Eye Research Institute
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94115
Scott, A B (1997) Preventing ptosis after botulinum treatment. Ophthal Plast Reconstr Surg 13:81-3
Scott, A B (1994) Change of eye muscle sarcomeres according to eye position. J Pediatr Ophthalmol Strabismus 31:85-8