Monocular congenital cataracts are generally associated with a poor visual outcome. Although removing a monocular cataract during early infancy improves the visual prognosis in the operated eye, the postoperative corrections of the resultant aphakia continues to be the limiting factor in the visual rehabilitation of these eyes. Correcting the aphakia with contact lenses, epikeratoplasty, or spectacles, magnifies the image in the aphakic eye, thereby creating a disparity in the image sizes between the phakic and aphakic eyes. Infants then suppress the image in the aphakic eye resulting in amblyopia, impaired binocularity and strabismus. This research project is a controlled study using a non-human primate model of a promising new approach to this problem that has the potential to optimize vision in the apakic eye and enhance the potential for binocular vision. Its major objectives are 1) to evaluate the safety and efficacy of intraocular lens implantation in infant; 2) to compare the utility of bifocal with monofocal pseudophakic correction; and 3) to determine whether occlusion therapy is required in monoculary pseudophakic infants in order to achieve good vision in both eyes. The effects of these interventions will be followed regularly in terms of visual acuity, ocular alignment, stereopsis, refractive error, corneal curvature, and axial elongation, and assessed histopathologically after 18 months. In addition, clinical and behavioral results will be compared with morphological changes in the lateral geniculate nucleus and the striate cortex.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY008544-03
Application #
3265911
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1990-09-30
Project End
1993-09-29
Budget Start
1992-09-30
Budget End
1993-09-29
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Emory University
Department
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Iuvone, P Michael; Haque, Rashidul; Fernandes, Alcides et al. (2015) Neonatal aphakia is associated with altered levels of dopamine metabolites in the non-human primate retina. Exp Eye Res 140:187-189
Tarnuzzer, Roy W; Fernandes, Alcides; Iuvone, P Michael et al. (2005) Neonatal aphakia retards ocular growth and alters scleral gene expression in rhesus monkeys. Mol Vis 11:36-49
Lenart, T D; Lambert, S R (2001) Slipped and lost extraocular muscles. Ophthalmol Clin North Am 14:433-42
Lambert, S R; Yang, L L; Stone, C (2000) Tonic pupil associated with congenital neuroblastoma, Hirschsprung disease, and central hypoventilation syndrome. Am J Ophthalmol 130:238-40
Boothe, R G; Louden, T; Aiyer, A et al. (2000) Visual outcome after contact lens and intraocular lens correction of neonatal monocular aphakia in monkeys. Invest Ophthalmol Vis Sci 41:110-9
Lenart, T D; Drack, A V; Tarnuzzer, R W et al. (2000) Heterochromia after pediatric cataract surgery. J AAPOS 4:40-5
Lenart, T D; Reichman, O S; McMahon, S J et al. (2000) Retrieval of lost medial rectus muscles with a combined ophthalmologic and otolaryngologic surgical approach. Am J Ophthalmol 130:645-52
Lambert, S R; Capone Jr, A; Cingle, K A et al. (2000) Cataract and phthisis bulbi after laser photoablation for threshold retinopathy of prematurity. Am J Ophthalmol 129:585-91
Lambert, S R (1999) Management of monocular congenital cataracts. Eye (Lond) 13 ( Pt 3b):474-9
Griener, E D; Dahan, E; Lambert, S R (1999) Effect of age at time of cataract surgery on subsequent axial length growth in infant eyes. J Cataract Refract Surg 25:1209-13

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