Abstract

Most of the axial growth of the eye occurs during the first two years of life. While the growth of the eye is usually precisely regulated by a process known as emmetropization, this process can become deranged in certain conditions resulting in excessive or retarded axial growth and large refractive errors. This project seeks to elucidate the molecular mechanisms responsible for the physiological processes that cause aberrant ocular growth with aphakia. Specifically, we will assay infantile eyes for changes in certain neurotransmitters and growth factors after removing the crystalline lens which we have previously shown retards ocular growth. Understanding the mechanisms whereby aphakia alter ocular growth is of vital importance in order to accurately select the most appropriate intraocular lens power to implant into infantile eyes after cataract surgery. In addition, by understanding the mechanisms retarding ocular growth, it may be possible to modulate the excessive ocular growth which occurs in certain pathological conditions such as retinopathy of prematurity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY008544-09
Application #
6150760
Study Section
Special Emphasis Panel (ZRG1-VISB (06))
Program Officer
Liberman, Ellen S
Project Start
1990-09-30
Project End
2002-01-31
Budget Start
2000-02-01
Budget End
2001-01-31
Support Year
9
Fiscal Year
2000
Total Cost
$228,582
Indirect Cost

  Institution

Name
Emory University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Iuvone, P Michael; Haque, Rashidul; Fernandes, Alcides et al. (2015) Neonatal aphakia is associated with altered levels of dopamine metabolites in the non-human primate retina. Exp Eye Res 140:187-189
Tarnuzzer, Roy W; Fernandes, Alcides; Iuvone, P Michael et al. (2005) Neonatal aphakia retards ocular growth and alters scleral gene expression in rhesus monkeys. Mol Vis 11:36-49
Lenart, T D; Lambert, S R (2001) Slipped and lost extraocular muscles. Ophthalmol Clin North Am 14:433-42
Lambert, S R; Yang, L L; Stone, C (2000) Tonic pupil associated with congenital neuroblastoma, Hirschsprung disease, and central hypoventilation syndrome. Am J Ophthalmol 130:238-40
Boothe, R G; Louden, T; Aiyer, A et al. (2000) Visual outcome after contact lens and intraocular lens correction of neonatal monocular aphakia in monkeys. Invest Ophthalmol Vis Sci 41:110-9
Lenart, T D; Drack, A V; Tarnuzzer, R W et al. (2000) Heterochromia after pediatric cataract surgery. J AAPOS 4:40-5
Lenart, T D; Reichman, O S; McMahon, S J et al. (2000) Retrieval of lost medial rectus muscles with a combined ophthalmologic and otolaryngologic surgical approach. Am J Ophthalmol 130:645-52
Lambert, S R; Capone Jr, A; Cingle, K A et al. (2000) Cataract and phthisis bulbi after laser photoablation for threshold retinopathy of prematurity. Am J Ophthalmol 129:585-91
Lambert, S R (1999) Management of monocular congenital cataracts. Eye (Lond) 13 ( Pt 3b):474-9
Griener, E D; Dahan, E; Lambert, S R (1999) Effect of age at time of cataract surgery on subsequent axial length growth in infant eyes. J Cataract Refract Surg 25:1209-13

Showing the most recent 10 out of 19 publications