Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY011018-02
Application #
2165253
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1995-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Bohren, Kurt M; Brownlee, June M; Milne, Amy C et al. (2005) The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism. Biochim Biophys Acta 1748:201-12
Barski, Oleg A; Siller-Lopez, Fernando; Bohren, Kurt M et al. (2004) Human aldehyde reductase promoter allows simultaneous expression of two genes in opposite directions. Biotechniques 36:382-4, 386, 388
Barski, Oleg A; Papusha, Victor Z; Kunkel, Gary R et al. (2004) Regulation of aldehyde reductase expression by STAF and CHOP. Genomics 83:119-29
Gabbay, Kenneth H (2004) Aldose reductase inhibition in the treatment of diabetic neuropathy: where are we in 2004? Curr Diab Rep 4:405-8
Sheikh-Hamad, D; Nadkarni, V; Choi, Y J et al. (2001) Cyclosporine A inhibits the adaptive responses to hypertonicity: a potential mechanism of nephrotoxicity. J Am Soc Nephrol 12:2732-41
Bohren, K M; Grimshaw, C E (2000) The sorbinil trap: a predicted dead-end complex confirms the mechanism of aldose reductase inhibition. Biochemistry 39:9967-74
Barski, O A; Gabbay, K H; Bohren, K M (1999) Characterization of the human aldehyde reductase gene and promoter. Genomics 60:188-98
Nadkarni, V; Gabbay, K H; Bohren, K M et al. (1999) Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase. J Biol Chem 274:20185-90
Harrison, D H; Bohren, K M; Petsko, G A et al. (1997) The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant. Biochemistry 36:16134-40
Ko, B C; Ruepp, B; Bohren, K M et al. (1997) Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene. J Biol Chem 272:16431-7

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