Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY011142-02
Application #
2019997
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1995-09-30
Project End
2000-09-29
Budget Start
1996-09-30
Budget End
1997-09-29
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cornell University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Bennett, Jean (2004) Gene therapy for Leber congenital amaurosis. Novartis Found Symp 255:195-202; discussion 202-7
Acland, G M; Aguirre, G D; Ray, J et al. (2001) Gene therapy restores vision in a canine model of childhood blindness. Nat Genet 28:92-5
Verdugo, M E; Scarpino, V; Moullier, P et al. (2001) Adenoviral vector-mediated beta-glucuronidase cDNA transfer to treat MPS VII RPE in vitro. Curr Eye Res 23:357-67
Kakkis, E D; Schuchman, E; He, X et al. (2001) Enzyme replacement therapy in feline mucopolysaccharidosis I. Mol Genet Metab 72:199-208
Verdugo, M E; Ailing, J; Lazar, E S et al. (2001) Posterior segment approach for subretinal transplantation or injection in the canine model. Cell Transplant 10:317-27
Ray, J; Scarpino, V; Laing, C et al. (1999) Biochemical basis of the beta-glucuronidase gene defect causing canine mucopolysaccharidosis VII. J Hered 90:119-23
Ray, J; Wolfe, J H; Aguirre, G D et al. (1998) Retroviral cDNA transfer to the RPE: stable expression and modification of metabolism. Invest Ophthalmol Vis Sci 39:1658-66
Ray, J; Haskins, M E; Ray, K (1998) Molecular diagnostic tests for ascertainment of genotype at the mucopolysaccharidosis type VII locus in dogs. Am J Vet Res 59:1092-5
Verdugo, M E; Ray, J (1997) Age-related increase in activity of specific lysosomal enzymes in the human retinal pigment epithelium. Exp Eye Res 65:231-40
Ray, J; Wu, Y; Aguirre, G D (1997) Characterization of beta-glucuronidase in the retinal pigment epithelium. Curr Eye Res 16:131-43