The long-term goal of this research is to understand the neural mechanisms underlying the perception of complex natural scenes in healthy and diseased visual systems. Unlike the stimuli used in traditional neurophysiological studies, most natural images are composed of multiple, frequently overlapping, objects. The ability to segment these images into component objects depends upon the detection and interpretation of regions of object overlap. This process is referred to as figure-ground interpretation. One objective of this proposal is to understand the neuronal basis of figure-ground interpretation. A physically salient object can be perceptually suppressed by the presence of another more salient object. This suppression underlies the ability to select one object as a target for action while ignoring other objects. A second objective of this proposal is to understand the neuronal mechanisms underlying this suppression. To achieve these objectives, a number of novel visual displays have been developed. To establish a correspondence between perceptual and neuronal events, a combination of behavioral and neurophysiological techniques will be used. Results from these experiments will lead to more refined models of visual processing and aid in the development of artificial sensory systems. In addition, this research will provide information for the treatment of brain-damaged and disease conditions that disrupt visual function.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY012872-08
Application #
7189029
Study Section
Visual Sciences B Study Section (VISB)
Program Officer
Oberdorfer, Michael
Project Start
1999-12-15
Project End
2008-11-30
Budget Start
2006-12-01
Budget End
2008-11-30
Support Year
8
Fiscal Year
2007
Total Cost
$460,512
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Jadi, Monika P; Sejnowski, Terrence J (2014) Cortical oscillations arise from contextual interactions that regulate sparse coding. Proc Natl Acad Sci U S A 111:6780-5
Kafaligonul, Hulusi; Stoner, Gene R (2012) Static sound timing alters sensitivity to low-level visual motion. J Vis 12:
Stoner, Gene R; Blanc, Georgina (2010) Exploring the mechanisms underlying surface-based stimulus selection. Vision Res 50:229-41
Kafaligonul, Hulusi; Stoner, Gene R (2010) Auditory modulation of visual apparent motion with short spatial and temporal intervals. J Vis 10:31
Huang, Xin; Albright, Thomas D; Stoner, Gene R (2008) Stimulus dependency and mechanisms of surround modulation in cortical area MT. J Neurosci 28:13889-906
van der Smagt, Maarten J; Stoner, Gene R (2008) Occlusion and the solution to visual motion ambiguity: Looking beyond the aperture problem. J Vis 8:4.1-12
Huang, Xin; Albright, Thomas D; Stoner, Gene R (2007) Adaptive surround modulation in cortical area MT. Neuron 53:761-70
Fallah, Mazyar; Stoner, Gene R; Reynolds, John H (2007) Stimulus-specific competitive selection in macaque extrastriate visual area V4. Proc Natl Acad Sci U S A 104:4165-9
Jordan, Heather; Fallah, Mazyar; Stoner, Gene R (2006) Adaptation of gender derived from biological motion. Nat Neurosci 9:738-9
Stoner, Gene R; Mitchell, Jude F; Fallah, Mazyar et al. (2005) Interacting competitive selection in attention and binocular rivalry. Prog Brain Res 149:227-34