One of the fundamental unanswered questions of sensory biology is how information provided by individual neurons within the brain is linked into a coherent whole. Individual visually responsive neurons only respond to stimulation over a limited portion of the visual image known as the receptive field. The proposed research addresses the question of how the visual system integrates this limited information into an accurate representation of that world. Specifically, this research focuses on the ability of the visual system to selectively integrate information that arises from the same visual object. The conventional view has been that visually responsive neurons have relatively fixed neuronal properties that are stimulus independent. Based on recent discoveries, this research hypothesizes instead that neurons adapt their response properties such that they selectively integrate only that information that arises from the same perceptual object. This research explores this hypothesis as it applies to the perception of visual motion and depth. The ability to appropriately integrate visual information is intrinsic to normal visual perception and cognition, and disruptions of that ability accompany ageing and mental pathologies such as schizophrenia. This research thus promises to provide insight into normal mental function and is pertinent to developing treatments of mental pathologies. The long term goal of this project is to provide insight into the neural events that underlie our perception of the world. Our detailed understanding of the brain mechanisms that underlie normal perception will ultimately aid the treatment and prevention of neurological and psychiatric disorders.
These aims are pertinent to the development of prosthetic and behavioral therapies for the visually handicapped.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY012872-10
Application #
7895572
Study Section
Central Visual Processing Study Section (CVP)
Program Officer
Steinmetz, Michael A
Project Start
1999-12-15
Project End
2012-01-31
Budget Start
2010-08-01
Budget End
2012-01-31
Support Year
10
Fiscal Year
2010
Total Cost
$609,961
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Jadi, Monika P; Sejnowski, Terrence J (2014) Cortical oscillations arise from contextual interactions that regulate sparse coding. Proc Natl Acad Sci U S A 111:6780-5
Kafaligonul, Hulusi; Stoner, Gene R (2012) Static sound timing alters sensitivity to low-level visual motion. J Vis 12:
Stoner, Gene R; Blanc, Georgina (2010) Exploring the mechanisms underlying surface-based stimulus selection. Vision Res 50:229-41
Kafaligonul, Hulusi; Stoner, Gene R (2010) Auditory modulation of visual apparent motion with short spatial and temporal intervals. J Vis 10:31
Huang, Xin; Albright, Thomas D; Stoner, Gene R (2008) Stimulus dependency and mechanisms of surround modulation in cortical area MT. J Neurosci 28:13889-906
van der Smagt, Maarten J; Stoner, Gene R (2008) Occlusion and the solution to visual motion ambiguity: Looking beyond the aperture problem. J Vis 8:4.1-12
Huang, Xin; Albright, Thomas D; Stoner, Gene R (2007) Adaptive surround modulation in cortical area MT. Neuron 53:761-70
Fallah, Mazyar; Stoner, Gene R; Reynolds, John H (2007) Stimulus-specific competitive selection in macaque extrastriate visual area V4. Proc Natl Acad Sci U S A 104:4165-9
Jordan, Heather; Fallah, Mazyar; Stoner, Gene R (2006) Adaptation of gender derived from biological motion. Nat Neurosci 9:738-9
Stoner, Gene R; Mitchell, Jude F; Fallah, Mazyar et al. (2005) Interacting competitive selection in attention and binocular rivalry. Prog Brain Res 149:227-34