The number of individuals affected by diabetes mellitus is rising at epidemic proportions, particularly in the Latino population of the United States. Diabetic retinopathy is one of most devastating complications of diabetes and is the leading cause of blindness in working age Americans. Even after accounting for other risk factors, such as blood sugar levels, Latinos appear to have higher rates of diabetic retinopathy compared with other ethnic groups. A National Eye Institute-funded study of Latino adults in Los Angeles revealed that nearly half of all Latino diabetics had evidence of diabetic retinopathy. Genetic factors have been suggested to play a role in the development of diabetes and diabetic retinopathy and may explain the apparent increased risk of developing these problems in the Latino population. We have hypothesized that identification of alleles with the strongest effect may be facilitated by studying patients with the most severe phenotypes or advanced complications of diabetes. In the present research program we propose to identify genetic risk factors for diabetic retinopathy by focusing on the Latino population in southern California who are affected by a severe diabetic microvascular complication, proliferative diabetic retinopathy (PDR). Our goal will be to recruit a large cohort of carefully phenotyped cases and controls which can be evaluated in subsequent genome wide association studies to identify genetic variants that predispose individuals to develop PDR.

Public Health Relevance

Identification of genetic factors that increase the susceptibility for developing proliferative diabetic retinopathy may provide new insights into the pathogenesis of these microvascular complications, which could lead to improved strategies for prevention and treatment. Given that diabetic retinopathy is the most common cause of blindness in working-age adults in the U.S., this research could have considerable public health benefit. An additional benefit of this research is its focus on the U.S. minority (Latino) population most severely impacted by this disease.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY019270-01A1
Application #
7736736
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Chin, Hemin R
Project Start
2009-09-01
Project End
2011-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
1
Fiscal Year
2009
Total Cost
$412,081
Indirect Cost
Name
Doheny Eye Institute
Department
Type
DUNS #
020738787
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
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