The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma and other diseases. Currently, there is no reliable method to perform measurements of corneal structural properties in vivo. Here we will develop a novel method for the topographical assessment of corneal elastic properties that could potentially be used for routine clinical diagnosis and monitoring of treatment. This method will take advantage of localized pulsed-air stimulation to generate microscopic pressure waves within the cornea and use phase-sensitive swept-source optical coherence tomography to detect and analyze the resultant pressure wave propagation within the cornea to reconstruct volumetric biomechanical properties of this tissue. Our long-term objectives are to use the coordinated talents of this research team to produce novel elasticity imaging instrumentation/methods that can extend our current understanding of the basic principles of tissue biomechanics and apply this knowledge to clinically relevant problems in ocular disease.

Public Health Relevance

This proposal will develop novel technology and methods for noninvasive reconstruction of biomechanical properties of the cornea. Development of such a technique would significantly advance our understanding of the corneal disorders, allow developing novel clinical therapies and interventions, and improve outcome of current surgical interventions including corneal refractive surgery.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-NT-L (09))
Program Officer
Wiggs, Cheri
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Houston
Engineering (All Types)
Schools of Engineering
United States
Zip Code
Liu, Chih-Hao; Nevozhay, Dmitry; Schill, Alexander et al. (2018) Nanobomb optical coherence elastography. Opt Lett 43:2006-2009
Kirillin, Mikhail Yu; Larin, Kirill V; Turchin, Ilya V et al. (2018) Special Section Guest Editorial: Topical Problems of Biophotonics: from Optical Bioimaging to Clinical Biophotonics. J Biomed Opt 23:1-2
Vantipalli, Srilatha; Li, Jiasong; Singh, Manmohan et al. (2018) Effects of Thickness on Corneal Biomechanical Properties Using Optical Coherence Elastography. Optom Vis Sci 95:299-308
Karpiouk, Andrei B; VanderLaan, Donald J; Larin, Kirill V et al. (2018) Integrated optical coherence tomography and multielement ultrasound transducer probe for shear wave elasticity imaging of moving tissues. J Biomed Opt 23:1-7
Zhang, Jitao; Raghunathan, Raksha; Rippy, Justin et al. (2018) Tissue biomechanics during cranial neural tube closure measured by Brillouin microscopy and optical coherence tomography. Birth Defects Res :
Loehr, James Anthony; Wang, Shang; Cully, Tanya R et al. (2018) NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice. Elife 7:
Singh, Manmohan; Han, Zhaolong; Li, Jiasong et al. (2018) Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography. J Cataract Refract Surg 44:1023-1031
Singh, Manmohan; Li, Jiasong; Han, Zhaolong et al. (2017) Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography. Biomed Opt Express 8:349-366
Larin, Kirill V; Sampson, David D (2017) Optical coherence elastography - OCT at work in tissue biomechanics [Invited]. Biomed Opt Express 8:1172-1202
Han, Zhaolong; Li, Jiasong; Singh, Manmohan et al. (2017) Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model. J Mech Behav Biomed Mater 66:87-94

Showing the most recent 10 out of 59 publications