Optical Coherence Elastography of the Cornea The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma. Currently, there is no available reliable method to perform measurement of corneal elasticity in vivo. Here we will develop novel method for the assessment of corneal elastic properties that could potentially be used for routine clinical diagnostic and treatment. This method will take advantages of highly localized air pressure stimulation and ultra-sensitive detection and analysis of the pressure waves propagation on corneal posterior and anterior surfaces with Optical Coherence Tomography to reconstruct volumetric biomechanical properties of the cornea. Our long-term objectives are to use the coordinated talents of this research team to produce novel elasticity imaging instrumentation/methods that can extend our current understanding of the basic principles of tissue biomechanics and apply this knowledge to clinically relevant problems in ocular disease.

Public Health Relevance

This proposal will focus on the development of novel technology and methods for noninvasive assessment of biomechanical properties of the cornea. Development of such a technique would significantly advance our understanding of the corneal disorders, allow developing novel clinical therapies and interventions, and improve outcome of current surgical interventions including corneal refractive surgery.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY022362-07
Application #
9684618
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Mckie, George Ann
Project Start
2012-06-01
Project End
2021-04-30
Budget Start
2019-05-01
Budget End
2021-04-30
Support Year
7
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Houston
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
036837920
City
Houston
State
TX
Country
United States
Zip Code
77204
Liu, Chih-Hao; Nevozhay, Dmitry; Schill, Alexander et al. (2018) Nanobomb optical coherence elastography. Opt Lett 43:2006-2009
Kirillin, Mikhail Yu; Larin, Kirill V; Turchin, Ilya V et al. (2018) Special Section Guest Editorial: Topical Problems of Biophotonics: from Optical Bioimaging to Clinical Biophotonics. J Biomed Opt 23:1-2
Vantipalli, Srilatha; Li, Jiasong; Singh, Manmohan et al. (2018) Effects of Thickness on Corneal Biomechanical Properties Using Optical Coherence Elastography. Optom Vis Sci 95:299-308
Karpiouk, Andrei B; VanderLaan, Donald J; Larin, Kirill V et al. (2018) Integrated optical coherence tomography and multielement ultrasound transducer probe for shear wave elasticity imaging of moving tissues. J Biomed Opt 23:1-7
Zhang, Jitao; Raghunathan, Raksha; Rippy, Justin et al. (2018) Tissue biomechanics during cranial neural tube closure measured by Brillouin microscopy and optical coherence tomography. Birth Defects Res :
Loehr, James Anthony; Wang, Shang; Cully, Tanya R et al. (2018) NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice. Elife 7:
Singh, Manmohan; Han, Zhaolong; Li, Jiasong et al. (2018) Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography. J Cataract Refract Surg 44:1023-1031
Lan, Gongpu; Singh, Manmohan; Larin, Kirill V et al. (2017) Common-path phase-sensitive optical coherence tomography provides enhanced phase stability and detection sensitivity for dynamic elastography. Biomed Opt Express 8:5253-5266
Liu, Chih-Hao; Schill, Alexander; Raghunathan, Raksha et al. (2017) Ultra-fast line-field low coherence holographic elastography using spatial phase shifting. Biomed Opt Express 8:993-1004
Singh, Manmohan; Li, Jiasong; Han, Zhaolong et al. (2017) Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography. Biomed Opt Express 8:349-366

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