The long-term objectives of this research program are to explore the molecular bases of a number of different cellular phenomena, all of which have in common the involvement of cell membranes. The specific problems to be investigated, which are outgrowths of our past studies on this grant, include the following: 1) the mechanisms of intracellular transport of secretory and integral membrane proteins from the endoplasmic reticulum to the Golgi apparatus; 2) the role of newly discovered membrane-bound tyrosin kinases, which are prominent components in the chick embryo, in embryonic development; 3)the mechanisms of signal transduction across membranes that result in massive cytoplasmic rearrangements and polarization inside the affected cells.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM015971-27
Application #
2170469
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1978-05-01
Project End
1996-04-30
Budget Start
1994-05-01
Budget End
1996-04-30
Support Year
27
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093