Abstract

Studies of the cyclic AMP control system in Neurospora are proceeding to determine the function and mechanism of the control system in fungi and other eukaryotic cells. Planned studies include characterization of the properties of the regulatory subunit of the cyclic AMP-dependent protein kinase and of a Mg 2 ion-dependent adenylate cyclase activity. These will be complemented by in vivo studies of the system through measurements of the control of endogenous cyclic AMP levels and the properties of cyclic AMP-deficient mutants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM024368-06
Application #
3272253
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1979-04-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Washington State University
Department
Type
Graduate Schools
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164

  Publications

Pall, M L; Robertson, C K (1988) Regulation of lactate/pyruvate ratios by cyclic AMP in Neurospora crassa. Biochem Biophys Res Commun 150:365-70
Pall, M L (1988) Cyclic AMP control of GTP pools in Saccharomyces cerevisiae. Biochem Biophys Res Commun 150:1144-8
Pall, M L; Robertson, C K (1988) Growth regulation by GTP. Regulation of nucleotide pools in Neurospora by nitrogen and sulfur control systems. J Biol Chem 263:11168-74
Dumbrava, V A; Pall, M L (1987) Regulation of fructose 2,6-bisphosphate levels in Neurospora crassa. Biochim Biophys Acta 925:210-7
Dumbrava, V A; Pall, M L (1987) Control of nucleotide and erythroascorbic acid pools by cyclic AMP in Neurospora crassa. Biochim Biophys Acta 926:331-8