Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM028289-16
Application #
2175149
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1980-12-01
Project End
1999-11-30
Budget Start
1995-12-15
Budget End
1996-11-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Ou, Wen-bin; Yi, Tingfang; Kim, Jong-Myoung et al. (2011) The roles of transmembrane domain helix-III during rhodopsin photoactivation. PLoS One 6:e17398
Kota, Parvathi; Reeves, Philip J; Rajbhandary, Uttam L et al. (2006) Opsin is present as dimers in COS1 cells: identification of amino acids at the dimeric interface. Proc Natl Acad Sci U S A 103:3054-9
Kim, Jong-Myoung; Hwa, John; Garriga, Pere et al. (2005) Light-driven activation of beta 2-adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops. Biochemistry 44:2284-92
Eilers, Markus; Ying, Weiwen; Reeves, Philip J et al. (2002) Magic angle spinning nuclear magnetic resonance of isotopically labeled rhodopsin. Methods Enzymol 343:212-22
Klein-Seetharaman, J; Reeves, P J; Loewen, M C et al. (2002) Solution NMR spectroscopy of [alpha -15N]lysine-labeled rhodopsin: The single peak observed in both conventional and TROSY-type HSQC spectra is ascribed to Lys-339 in the carboxyl-terminal peptide sequence. Proc Natl Acad Sci U S A 99:3452-7
Reeves, Philip J; Kim, Jong-Myoung; Khorana, H Gobind (2002) Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants. Proc Natl Acad Sci U S A 99:13413-8
Niu, Li; Kim, Jong-Myoung; Khorana, H Gobind (2002) Structure and function in rhodopsin: asymmetric reconstitution of rhodopsin in liposomes. Proc Natl Acad Sci U S A 99:13409-12
Reeves, Philip J; Callewaert, Nico; Contreras, Roland et al. (2002) Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line. Proc Natl Acad Sci U S A 99:13419-24
Cai, K; Itoh, Y; Khorana, H G (2001) Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: use of a photoactivatable reagent. Proc Natl Acad Sci U S A 98:4877-82
Kim, J M; Booth, P J; Allen, S J et al. (2001) Structure and function in bacteriorhodopsin: the role of the interhelical loops in the folding and stability of bacteriorhodopsin. J Mol Biol 308:409-22

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