Abstract

The overall objective of this research program is to develop a flexible route for the synthesis of vinblastine, a potent chemotherapeutic agent used for treating Hodgkins disease, choriocarcinoma acute leukemia in children and other malignant conditions. The low natural abundance of vinblastine, and paucity of simpler analog testing, make this an important objective. It is intended to develop the chemistry to make the components in a chiral form, and to link the two alkaloid units together in a simpler form at an early stage. In this way, complicated dimeric indole alkaloids, with a similar topology to natural vinblastine, can be made and biologically evaluated en route to vinblastine itself.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029801-06
Application #
3277463
Study Section
(SSS)
Project Start
1982-04-01
Project End
1988-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Indiana University Bloomington
Department
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47402

  Publications

Lynch, V M; Stamford, A; Magnus, P et al. (1991) Structure of a novel bisindole derivative. Acta Crystallogr C 47 ( Pt 6):1342-5
Lynch, V M; Stamford, A; Magnus, P et al. (1991) Structure of 18'-epivinblastine. Acta Crystallogr C 47 ( Pt 7):1563-6