Abstract

(i) To complete the synthesis of the antitumor agent vinblastine. (ii) To investigate the mechanism of the coupling reaction. (iii) To synthesize rationally designed analogs on the basis of the proposed mechanism of action. In conjugation with both in vitro and in vivo biological assay, we hope to be able to develop a more complete picture of the structural features necessary for anticancer activity, and tubulin binding.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029801-10
Application #
3277465
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1989-01-01
Project End
1991-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
10
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Texas Austin
Department
Type
Schools of Arts and Sciences
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712

  Publications

Lynch, V M; Stamford, A; Magnus, P et al. (1991) Structure of a novel bisindole derivative. Acta Crystallogr C 47 ( Pt 6):1342-5
Lynch, V M; Stamford, A; Magnus, P et al. (1991) Structure of 18'-epivinblastine. Acta Crystallogr C 47 ( Pt 7):1563-6