Support is requested for five years to conduct theoretical and computer simulation studies which arise out of attempts to apply current models and methods of quantitative genetic analysis to human data. The issues we hope to address are: 1. How far we can detect the genetic control of sensitivity to indices of the environment (""""""""genotype x environment interaction""""""""); 2. The simultaneous genetic analysis of multiple variables including a study of: errors arising as a result of misspecifying models for environmental indices; issues in the design and analysis of studies designed to measure genetic covariation between measures; 3. statistical difficulties associated with trying to apply path models to discontinuous data; 4. errors which can occur in trying to detect genes of large effect against a background of polygenic variation. Each of these issues will be addressed by simulating data under a different mechanism of inheritance. By fitting the """"""""right"""""""" model and attempting to devise simple statistical tests of particular hypotheses we shall determine the reliability with which particular effects may be detected and efficient estimates of the population parameters be recovered. By fitting """"""""wrong"""""""" models, we shall find out how often investigators could come to the wrong conclusions and base further developments on false explanation of their data.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM030250-07
Application #
3277904
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1982-02-01
Project End
1991-01-31
Budget Start
1988-02-01
Budget End
1989-01-31
Support Year
7
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
Overall Medical
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
van den Berg, Stéphanie M; de Moor, Marleen H M; McGue, Matt et al. (2014) Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behav Genet 44:295-313
Bergin, Jocilyn E; Neale, Michael C; Eaves, Lindon J et al. (2012) Genetic and environmental transmission of body mass index fluctuation. Behav Genet 42:867-74
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Maes, Hermine H; Neale, Michael C; Kendler, Kenneth S et al. (2006) Genetic and cultural transmission of smoking initiation: an extended twin kinship model. Behav Genet 36:795-808
Turkheimer, Eric; D'Onofrio, Brian M; Maes, Hermine H et al. (2005) Analysis and interpretation of twin studies including measures of the shared environment. Child Dev 76:1217-33
Bulik, C M; Wade, T D; Heath, A C et al. (2001) Relating body mass index to figural stimuli: population-based normative data for Caucasians. Int J Obes Relat Metab Disord 25:1517-24
Eaves, L; Heath, A; Martin, N et al. (1999) Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30,000 study of twins and their relatives. Twin Res 2:62-80
Maes, H H; Neale, M C; Martin, N G et al. (1999) Religious attendance and frequency of alcohol use: same genes or same environments: a bivariate extended twin kinship model. Twin Res 2:169-79
Eaves, L J; Heath, A C; Neale, M C et al. (1998) Sex differences and non-additivity in the effects of genes on personality. Twin Res 1:131-7

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