Protocols are offered by which ongoing synthetic efforts should culminate in the acquisition of: (a) pleuromutilin, a diterpene antibiotic produced by several basidiomycetes; (b) sterpuric acid, a sesquiterpenoid metabolite of the fungus Stereum purpureum; and (c) 3Beta-hydroxy-7Beta-kemp-8(9)-en-6-one, a cembrene-derived diterpene produced by nasute termite soldiers. In addition, new efforts are outlined for the purpose of developing new methodologies that will culminate in the laboratory preparation of: (d) acetoxycrenulide, a unique bicyclic cyclopropane-containing diterpenoid exuded by small brown phaeophyta; (e) 7,8-epoxy-4-basmen-6-one, a tricyclic diterpenoid of unusual structure produced by certain types of Oriental tobacco; (f) jatrophatrione, a tricyclic triketo diterpene possessing a 5/9/5-fused ring skeleton that exhibits good inhibitory activity toward the P-388 (3PS) lymphocytic leukemia test system; (g) neolemnanyl acetate, an irregular sesquiterpene produced by the Pacific soft coral Lemnalia africana; (h) cerorubenic acid-III, a kairomone secreted by Ceroplastes rubens recognized for its ability to control the ovipositional behavior of certain insects; and (i) punctatin A, a product of the dung fungus Poronia punctata that is reputed for its antibiotic activity.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM030827-04
Application #
3278717
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1983-04-01
Project End
1991-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
Schools of Arts and Sciences
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210