Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032224-06
Application #
3280863
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1984-12-01
Project End
1990-08-31
Budget Start
1989-12-01
Budget End
1990-08-31
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903
Ulland, A E; Shearer, J D; Coulter, C et al. (1997) Altered wound arginine metabolism by corticosterone and retinoic acid. J Surg Res 70:84-8
Shearer, J D; Richards, J R; Mills, C D et al. (1997) Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am J Physiol 272:E181-90
Shearer, J D; Coulter, C F; Engeland, W C et al. (1997) Insulin is degraded extracellularly in wounds by insulin-degrading enzyme (EC 3.4.24.56). Am J Physiol 273:E657-64
Caldwell, M D; Mastrofrancesco, B; Shearer, J et al. (1991) The temporal change in amino acid concentration within wound fluid--a putative rationale. Prog Clin Biol Res 365:205-22
Mills, C D; Pricolo, V E; Albina, J E et al. (1991) Concomitant macrophage activation and fibroblast/lymphocyte inhibition by wound fluid: the ""arginine-deficiency of inflammation"" is a partial explanation. Prog Clin Biol Res 365:193-203
Daley, J M; Shearer, J D; Mastrofrancesco, B et al. (1990) Glucose metabolism in injured tissue: a longitudinal study. Surgery 107:187-92
Falcone, P A; Caldwell, M D (1990) Wound metabolism. Clin Plast Surg 17:443-56
Albina, J E; Caldwell, M D; Henry Jr, W L et al. (1989) Regulation of macrophage functions by L-arginine. J Exp Med 169:1021-9
Albina, J E; Mills, C D; Henry Jr, W L et al. (1989) Regulation of macrophage physiology by L-arginine: role of the oxidative L-arginine deiminase pathway. J Immunol 143:3641-6
Forster, J; Morris, A S; Shearer, J D et al. (1989) Glucose uptake and flux through phosphofructokinase in wounded rat skeletal muscle. Am J Physiol 256:E788-97

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