The aim of this proposal is to identify the scope and limitations of bridgehead carbocations in organic synthesis. The synthesis of polycyclic natural products containing bicyclo[2.2.2]octane, bicyclo[3.2.1]octane and bicyclo[3.3.1]nonane subunits will be accomplished. Biologically significant molecules such as aphidicolin (anticancer agent, antiviral agent) will be synthesized. Since bridgehead carbocations have not been previously employed in synthesis, this proposal should make available new and efficient synthetic pathways.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM033604-03
Application #
3283517
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1985-09-01
Project End
1988-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Iowa State University
Department
Type
Schools of Arts and Sciences
DUNS #
City
Ames
State
IA
Country
United States
Zip Code
50011