The overall goal is to understand the chemistry of bridgehead intermediates and to apply this knowledge to the total synthesis of natural products. The specific goals include 1) the synthesis of the potent antitumor agent shikodonin; 2) the synthesis of colchicine and a heteroatom analog. Colchicine is an inhibitor of mitosis by affecting the action of microtubules; 3) the study of a rearrangement of a bridged ring system to a fused bicyclo(3.3.0) ring system. An immediate application is the antibiotic pentalenolactone E; and 4) the study of the cycloadditions of bridgehead enals with electron-rich alkenes. An immediate application is the isocedrene class of sesquiterpenes.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM033604-06
Application #
3283519
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1985-09-01
Project End
1992-08-31
Budget Start
1990-09-01
Budget End
1991-08-31
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Iowa State University
Department
Type
Schools of Arts and Sciences
DUNS #
City
Ames
State
IA
Country
United States
Zip Code
50011