Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM036139-03
Application #
3289694
Study Section
Metabolism Study Section (MET)
Project Start
1986-01-01
Project End
1988-07-31
Budget Start
1988-01-01
Budget End
1988-07-31
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Martin, L F; Vary, T C; Davis, P K et al. (1991) Intravascular plastic catheters. How they potentiate tumor necrosis factor release and exacerbate complications associated with sepsis. Arch Surg 126:1087-93
Vary, T C (1991) Increased pyruvate dehydrogenase kinase activity in response to sepsis. Am J Physiol 260:E669-74
Vary, T C; Murphy, J M (1989) Role of extra-splanchnic organs in the metabolic response to sepsis: effect of insulin. Circ Shock 29:41-57
Vary, T C; Siegel, J H; Tall, B et al. (1989) Role of anaerobic bacteria in intra-abdominal septic abscesses in mediating septic control of skeletal muscle glucose oxidation and lactic acidemia. J Trauma 29:1003-13;discussion 1013-4
Vary, T C; Placko, R; Siegel, J H (1989) Pharmacologic modulation of increased release of gluconeogenic precursors from extra-splanchnic organs in sepsis. Circ Shock 29:59-76
Vary, T C; Siegel, J H; Placko, R et al. (1989) Effect of dichloroacetate on plasma and hepatic amino acids in sterile inflammation and sepsis. Arch Surg 124:1071-7
Vary, T C; Siegel, J H; Zechnich, A et al. (1988) Pharmacological reversal of abnormal glucose regulation, BCAA utilization, and muscle catabolism in sepsis by dichloroacetate. J Trauma 28:1301-11
Vary, T C; Siegel, J H; Tall, B D et al. (1988) Inhibition of skeletal muscle protein synthesis in septic intra-abdominal abscess. J Trauma 28:981-8
Vary, T C; Siegel, J H; Tall, B D et al. (1988) Metabolic effects of partial reversal of pyruvate dehydrogenase activity by dichloroacetate in sepsis. Circ Shock 24:3-18
Vary, T C; Siegel, J H; Nakatani, T et al. (1986) Regulation of glucose metabolism by altered pyruvate dehydrogenase activity. I. Potential site of insulin resistance in sepsis. JPEN J Parenter Enteral Nutr 10:351-5

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