Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM036537-04A1
Application #
3290695
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1985-09-01
Project End
1989-08-31
Budget Start
1988-12-01
Budget End
1989-08-31
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
Overall Medical
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Kassenbrock, C K; Cao, W; Douglas, M G (1993) Genetic and biochemical characterization of ISP6, a small mitochondrial outer membrane protein associated with the protein translocation complex. EMBO J 12:3023-34
Yuan, H; Douglas, M G (1992) The mitochondrial F1ATPase alpha-subunit is necessary for efficient import of mitochondrial precursors. J Biol Chem 267:14697-702
Cyr, D M; Lu, X; Douglas, M G (1992) Regulation of Hsp70 function by a eukaryotic DnaJ homolog. J Biol Chem 267:20927-31
Cyr, D M; Douglas, M G (1991) Early events in the transport of proteins into mitochondria. Import competition by a mitochondrial presequence. J Biol Chem 266:21700-8
Hoyt, D W; Cyr, D M; Gierasch, L M et al. (1991) Interaction of peptides corresponding to mitochondrial presequences with membranes. J Biol Chem 266:21693-9
Smagula, C; Douglas, M G (1988) Mitochondrial import of the ADP/ATP carrier protein in Saccharomyces cerevisiae. Sequences required for receptor binding and membrane translocation. J Biol Chem 263:6783-90
Chen, W J; Douglas, M G (1988) An F1-ATPase beta-subunit precursor lacking an internal tetramer-forming domain is imported into mitochondria in the absence of ATP. J Biol Chem 263:4997-5000
Chen, W J; Douglas, M G (1987) The role of protein structure in the mitochondrial import pathway. Analysis of the soluble F1-ATPase beta-subunit precursor. J Biol Chem 262:15598-604
Vassarotti, A; Chen, W J; Smagula, C et al. (1987) Sequences distal to the mitochondrial targeting sequences are necessary for the maturation of the F1-ATPase beta-subunit precursor in mitochondria. J Biol Chem 262:411-8
Chen, W J; Douglas, M G (1987) Phosphodiester bond cleavage outside mitochondria is required for the completion of protein import into the mitochondrial matrix. Cell 49:651-8

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