Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM039754-10
Application #
2180011
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1988-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
State University of New York at Buffalo
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260

  Publications

Zhai, Xiang; Reinhardt, Christopher J; Malabanan, M Merced et al. (2018) Enzyme Architecture: Amino Acid Side-Chains That Function To Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase. J Am Chem Soc 140:8277-8286
Reyes, Archie C; Amyes, Tina L; Richard, John P (2018) Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase. Biochemistry 57:4338-4348
Richard, John P; Amyes, Tina L; Reyes, Archie C (2018) Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis. Acc Chem Res 51:960-969
Kulkarni, Yashraj S; Liao, Qinghua; Byléhn, Fabian et al. (2018) Role of Ligand-Driven Conformational Changes in Enzyme Catalysis: Modeling the Reactivity of the Catalytic Cage of Triosephosphate Isomerase. J Am Chem Soc 140:3854-3857
Amyes, T L; Malabanan, M M; Zhai, X et al. (2017) Enzyme activation through the utilization of intrinsic dianion binding energy. Protein Eng Des Sel 30:157-165
Amyes, Tina L; Richard, John P (2017) Substituent Effects on Carbon Acidity in Aqueous Solution and at Enzyme Active Sites. Synlett 28:2407-2421
Amyes, Tina L; Richard, John P (2017) Primary Deuterium Kinetic Isotope Effects From Product Yields: Rationale, Implementation, and Interpretation. Methods Enzymol 596:163-177
Reyes, Archie C; Amyes, Tina L; Richard, John P (2017) Enzyme Architecture: Erection of Active Orotidine 5'-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes. J Am Chem Soc 139:16048-16051
Reyes, Archie C; Amyes, Tina L; Richard, John P (2017) A reevaluation of the origin of the rate acceleration for enzyme-catalyzed hydride transfer. Org Biomol Chem 15:8856-8866
Reyes, Archie C; Amyes, Tina L; Richard, John P (2016) Structure-Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase. J Am Chem Soc 138:14526-14529

Showing the most recent 10 out of 76 publications