Mechanistic Studies of Oxygen Pathology

Dix, Thomas A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 2R01GM040338-04A3
• Application #: 2180274
• Study Section: Chemical Pathology Study Section (CPA)
• Project Start: 1990-04-01
• Project End: 1999-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Medical University of South Carolina
• Department: Pharmacology
• Type: Schools of Pharmacy
• DUNS #: 183710748
• City: Charleston
• State: SC
• Country: United States
• Zip Code: 29425

Publications

Simandan, T; Sun, J; Dix, T A (1998) Oxidation of DNA bases, deoxyribonucleosides and homopolymers by peroxyl radicals. Biochem J 335 ( Pt 2):233-40

Dix, T A; Hess, K M; Medina, M A et al. (1996) Mechanism of site-selective DNA nicking by the hydrodioxyl (perhydroxyl) radical. Biochemistry 35:4578-83

Aikens, J; Dix, T A (1993) Hydrodioxyl (perhydroxyl), peroxyl, and hydroxyl radical-initiated lipid peroxidation of large unilamellar vesicles (liposomes): comparative and mechanistic studies. Arch Biochem Biophys 305:516-25

Aikens, J; Dix, T A (1992) Effect of solution ionic strength on lipid peroxidation initiation by the perhydroxyl (xanthine oxidase-derived) and peroxyl radicals. Chem Res Toxicol 5:263-7

Hess, K M; Dix, T A (1992) Evaluation of N-hydroxy-2-thiopyridone as a nonmetal dependent source of the hydroxyl radical (HO.) in aqueous systems. Anal Biochem 206:309-14

Aikens, J; Dix, T A (1991) Perhydroxyl radical (HOO.) initiated lipid peroxidation. The role of fatty acid hydroperoxides. J Biol Chem 266:15091-8