Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM041303-09
Application #
2180798
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1991-07-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1998-08-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Surgery
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Liu, W Robert; Lu, Leonard; Rosenberg, David S et al. (2007) Synergistic activation of extracellular signal-regulated kinase in human dermal fibroblasts by human telomerase reverse transcriptase and transforming growth factor-beta1. J Surg Res 143:415-21
Sisco, Mark; Liu, W Robert; Kryger, Zol B et al. (2007) Reduced up-regulation of cytoprotective genes in rat cutaneous tissue during the second cycle of ischemia-reperfusion. Wound Repair Regen 15:203-12
Mogford, Jon E; Liu, W Robert; Reid, Russell et al. (2006) Adenoviral human telomerase reverse transcriptase dramatically improves ischemic wound healing without detrimental immune response in an aged rabbit model. Hum Gene Ther 17:651-60
Bengali, Zain; Pannier, Angela K; Segura, Tatiana et al. (2005) Gene delivery through cell culture substrate adsorbed DNA complexes. Biotechnol Bioeng 90:290-302
Gurjala, Anandev N; Liu, W Robert; Mogford, Jon E et al. (2005) Age-dependent response of primary human dermal fibroblasts to oxidative stress: cell survival, pro-survival kinases, and entrance into cellular senescence. Wound Repair Regen 13:565-75
Mogford, Jon E; Sisco, Mark; Bonomo, Steve R et al. (2004) Impact of aging on gene expression in a rat model of ischemic cutaneous wound healing. J Surg Res 118:190-6
Mogford, Jon E; Roy, Nakshatra K; Cross, Kevin J et al. (2003) Use of hypoxia-inducible factor signal transduction pathway to measure O2 levels and modulate growth factor pathways. Wound Repair Regen 11:496-503
Xia, Y P; Zhao, Y; Tyrone, J W et al. (2001) Differential activation of migration by hypoxia in keratinocytes isolated from donors of increasing age: implication for chronic wounds in the elderly. J Invest Dermatol 116:50-6
Wu, L; Xia, Y P; Roth, S I et al. (1999) Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: importance of oxygen and age. Am J Pathol 154:301-9
Abbott, R E; Corral, C J; MacIvor, D M et al. (1998) Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice. Arch Surg 133:1002-6

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