Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM046134-04A2
Application #
2183674
Study Section
Special Emphasis Panel (ZRG2-ALY (01))
Project Start
1992-02-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Alam, S Munir; Gascoigne, Nicholas R J (2003) Binding kinetics of superantigen with TCR and MHC class II. Methods Mol Biol 214:65-85
Redpath, S; Ghazal, P; Gascoigne, N R (2001) Hijacking and exploitation of IL-10 by intracellular pathogens. Trends Microbiol 9:86-92
McGuire, M V; Suthipinijtham, P; Gascoigne, N R (2001) The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus. Mamm Genome 12:664-7
Gascoigne, N R; Alam, S M; Lin, C M et al. (2000) T cell receptor binding kinetics and special role of Valpha in T cell development and activation. Immunol Res 21:225-31
Redpath, S; Alam, S M; Lin, C M et al. (1999) Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands. J Immunol 163:6-10
Redpath, S; Angulo, A; Gascoigne, N R et al. (1999) Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10. J Immunol 162:6701-7
Ghoshroy, S; Freedman, K; Lartey, R et al. (1998) Inhibition of plant viral systemic infection by non-toxic concentrations of cadmium. Plant J 13:591-602
Sheng, J; Lartey, R; Ghoshroy, S et al. (1998) An Arabidopsis thaliana mutant with virus-inducible phenotype. Virology 249:119-28
Lartey, R T; Ghoshroy, S; Citovsky, V (1998) Identification of an Arabidopsis thaliana mutation (vsm1) that restricts systemic movement of tobamoviruses. Mol Plant Microbe Interact 11:706-9
Wung, J L; Gascoigne, N R (1997) Selection of phage-displayed superantigen by binding to cell-surface MHC class II. J Immunol Methods 204:33-41

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