Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM048614-03
Application #
2186114
Study Section
Experimental Immunology Study Section (EI)
Project Start
1994-08-01
Project End
1997-11-30
Budget Start
1996-08-01
Budget End
1997-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Hampton, Mark B; Stamenkovic, Ivan; Winterbourn, Christine C (2002) Interaction with substrate sensitises caspase-3 to inactivation by hydrogen peroxide. FEBS Lett 517:229-32
Fiore, Emilio; Fusco, Carlo; Romero, Pedro et al. (2002) Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity. Oncogene 21:5213-23
Yu, Wei-Hsuan; Woessner Jr, J Frederick; McNeish, John D et al. (2002) CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes Dev 16:307-23
Stamenkovic, I (2000) Matrix metalloproteinases in tumor invasion and metastasis. Semin Cancer Biol 10:415-33
Yu, Q; Stamenkovic, I (2000) Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14:163-76
Peterson, R M; Yu, Q; Stamenkovic, I et al. (2000) Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites. Am J Pathol 156:2159-67
Biancone, L; Cantaluppi, V; Boccellino, M et al. (1999) Activation of CD40 favors the growth and vascularization of Kaposi's sarcoma. J Immunol 163:6201-8
Biancone, L; Stamenkovic, I; Cantaluppi, V et al. (1999) Expression of L-selectin ligands by transformed endothelial cells enhances T cell-mediated rejection. J Immunol 162:5263-9
Yu, Q; Stamenkovic, I (1999) Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev 13:35-48
Barnes, Y C; Skelton, T P; Stamenkovic, I et al. (1999) Sialylation of the sialic acid binding lectin sialoadhesin regulates its ability to mediate cell adhesion. Blood 93:1245-52

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