Four aims are proposed: (1) to explore the role of mapmodulin in living cells by determining the consequences of overexpression, reduced expression or antibody sequestration; (2) to explore a possible link between cytoplasmic dynein and mapmodulin; (3) to carry out invitro experiments to examine the influence of mapmodulin on dynein- or kinesin- mediated microtubule gliding; and ($) to further characterize a new Golgi-specific dynein and a novel Golgi-microtubule linking factor.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM049843-05A1
Application #
2616963
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Haft, Carol Renfrew
Project Start
1993-08-01
Project End
2002-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Stanford University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305